The noticed deficiency of a big accumulation of PHN in Mind subsequent the intraventricular administration of (+)-amphetamine and the formation of appreciable quantities of PHN from (+)-POH in brain tissue in vivo supports the watch which the aromatic hydroxylation of amphetamine pursuing its systemic administration occurs predominantly inside the periphery, Which POH is then transported through the blood-brain barrier, taken up by noradrenergic neurones in brain where (+)-POH is transformed in the storage vesicles by dopamine β-hydroxylase to PHN. ^
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